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Journey through the heart of America.

Discover the legendary Mississippi River, where history, culture and cuisine come to life. Aboard American Cruise Lines' intimate ships, explore storied battlefields and legendary music cities, all while savoring the rich flavors of the south.

Receive complimentary airfare and up to $1,500 savings on select 2025 sailings.*

131-140 of 150 results
Memphis/New Orleans
8-night Lower Mississippi River Cruise
November 11, 2025
American Cruise Lines: American Splendor (formerly America®)
Memphis/New Orleans
Vacation Offer ID 1563866
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Exclusive Offer
  • $100 per Couple Shipboard Credit*
Roundtrip New Orleans
7-night Historic Mississippi River Cruise
November 11, 2025
American Cruise Lines: American Symphony
Roundtrip New Orleans
Vacation Offer ID 1596861
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Exclusive Offer
  • $100 per Couple Shipboard Credit*
New Orleans/Memphis
8-night Lower Mississippi River Cruise
November 14, 2025
American Cruise Lines: American Melody
New Orleans/Memphis
Vacation Offer ID 1563249
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Exclusive Offer
  • $100 per Couple Shipboard Credit
Roundtrip New Orleans
7-night Historic Mississippi River Cruise
November 15, 2025
American Cruise Lines: American Heritage (formerly Queen of the Mississippi)
Roundtrip New Orleans
Vacation Offer ID 1562298
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Exclusive Offer
  • $100 per Couple Shipboard Credit
Roundtrip New Orleans
7-night Historic Mississippi River Cruise
November 16, 2025
American Cruise Lines: American Serenade
Roundtrip New Orleans
Vacation Offer ID 1563400
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Exclusive Offer
  • $100 per Couple Shipboard Credit
Roundtrip New Orleans
7-night Historic Mississippi River Cruise
November 17, 2025
American Cruise Lines: American Symphony
Roundtrip New Orleans
Vacation Offer ID 1596862
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Exclusive Offer
  • $100 per Couple Shipboard Credit*
Memphis/New Orleans
8-night Lower Mississippi River Cruise
November 21, 2025
American Cruise Lines: American Melody
Memphis/New Orleans
Vacation Offer ID 1563255
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Exclusive Offer
  • $100 per Couple Shipboard Credit
Roundtrip New Orleans
7-night Historic Mississippi River Cruise
November 22, 2025
American Cruise Lines: American Serenade
Roundtrip New Orleans
Vacation Offer ID 1563401
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Exclusive Offer
  • $100 per Couple Shipboard Credit
Roundtrip New Orleans
7-night Historic Mississippi River Cruise
November 23, 2025
American Cruise Lines: American Symphony
Roundtrip New Orleans
Vacation Offer ID 1596863
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Exclusive Offer
  • $100 per Couple Shipboard Credit*
Roundtrip New Orleans
7-night Historic Mississippi River Cruise
November 28, 2025
American Cruise Lines: American Melody
Roundtrip New Orleans
Vacation Offer ID 1563262
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Exclusive Offer
  • $100 per Couple Shipboard Credit

*Savings per stateroom are based on limited availability. Certain restrictions apply. Ship, itinerary, savings, and schedules are subject to change. Complimentary airfare is for domestic flights only. Valid on new bookings only. This offer does not apply to groups. Information and pricing are subject to change without notice, including changes in the currency exchange rate. All prices are per person, cruise or land only, based on double occupancy, unless otherwise noted. Prices may vary by day of travel, season, duration, and are subject to availability at time of booking. Certain blackout dates may apply. Airfares are not included except where noted. Air, immigration, and taxes are not included unless noted. All offers and upgrades are for select dates, and select room or cabin categories, subject to availability, and are capacity controlled. Cruise fares shown are the lowest available nationwide non-past-passenger fare. Other fares, which may be lower and/or include restrictions, may be available. Please view the full offer for complete details. All efforts have been made to ensure the accuracy of the information contained herein. Should an error occur, we reserve the right to correct it. Additional terms and conditions may apply. CST #2079194-10